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ATCC
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Image Search Results
Journal: Journal of nanobiotechnology
Article Title: ROS-responsive liposomes as an inhaled drug delivery nanoplatform for idiopathic pulmonary fibrosis treatment via Nrf2 signaling.
doi: 10.1186/s12951-022-01435-4
Figure Lengend Snippet: Fig. 7 DTP@DMF NPs suppress fibrosis and macrophage accumulation in lung tissue via Nrf2 signaling. a Representative H&E and Masson’s trichrome staining and b the severity score of fibrosis after DMF, DP@DMF NPs and DTP@DMF NPs treatment (n = 5). c α-SMA and d collagen Ia1 protein levels in fibrotic tissue (n = 3). e Nrf2 and f HO-1 levels in fibrotic tissue (n = 3). g The Nrf2 (red) and HO-1 (red) expression in F4/80+ macrophages (green) detected by immunofluorescence analysis. h Immunohistochemistry of F4/80+, CD86+, and CD206+ macrophages in pulmonary tissues, and i–m quantification of total macrophages and M1 and M2 phenotypes (n = 5). n TGF-β levels in BALF, o SOD and p MDA levels in tissue (n = 5). Statistical analyses were performed via one-way ANOVA with S–N-K post hoc analysis. * P < 0.05, ** P < 0.01, *** P < 0.001
Article Snippet: Antibodies against Nrf2, collagen Ia1,
Techniques: Staining, Expressing, Immunofluorescence, Immunohistochemistry